Nizam's Institute of Medical Sciences

(A University Established Under State Act)

Hyderabad - 500082, Telangana, India


Ongoing Researches:
  • Evaluation of minimal residual disease detection by flow cytometry in treated cased of acute leukemia, comparison with morphological assessment and role in patient management.
  • Study of clinical and morphological features of meduvoblastoma withimmunohistochemical characterization of molecular subtypes.
  • Utility of bone marrow trephine biopsy in pyrexia of unknown origin.
  • Immunohistochemical study of mismatch repair protein expression in colorectal carcinomas.
  • Laboratory testing for lupus anticoagulants. A study from tertiary care referral centre.
  • Muscle biopsy in congenital myopathies: correlation of clinical phenotype with biopsy features
  • Clinicopathologic and molecular characteristics of ependymoma
  • Clinicopathological and Immunohistochemical study of gastrointestinal tract lymphomas
  • Expression of SOX10 Immunohistochemistry in triple negative breast cancer
  • Detection of Paroxysmal nocturnal hemoglobinuria (PNH) clones and its clinical correlation. A Multiparametric Flow cytometry based study
  • SATB2 Immunohistochemistry in osteosarcoma: Utility in diapnosis and differcutition from histalogic mimics
  • Immunophenotypic study of lymphoproliferative disorders on bone marrow and peripheral blood.
  • NKX2.2 Immunohistochemistry in Ewings sarcoma and its histological mimics


Completed Researches:
  • Clinicopathological and Immunohistochemistry of Gastro intestinal stromal tumor (GISTS)
  • Identification of basal subtype of breast carcinoma in triple negative breast cancers by immunohistochemistry with cytokeratin 5/6
  • New Oxford classification for IgA Nephropathy: Applicability in Indian setting
  • Clinical and Immunohistochemical characterization of pituitary Adenomas
  • Utility of Platelet Indices in Thrombocytosis
  • Clinicopathological Study of Renal Biopsy Proven Acute Post Infectious Glomerulonephritis.
  • Tissue microarray based immunohistochemical study of TLE1 in Synovial Sarcoma and its histologic mimics
  • Chronic lympho proliferative disorders - morphologic and immunophenotypic study on blood and bone marrow
  • Correlation of Ki-67 Labeling Index with SBR Grade in Primary Breast Carcinoma
  • Clinicopathologic study of Vascular malformations of cental nervous system
  • Acute promyelocytic leukemia (APL) A study based on clinical, pathologic, immunophenotypic, cytogenetic and molecular features.
  • Anaplastic large cell lymphoma (ALCL): A clinicopathologic study along with IHC profile.
  • Clinicopathological study of Image-guided percutaneous core needle biopsy of Lung
  • Clinicopathological study of Neuroendocrine tumors of Gastrointestinal tract and pancreas
  • Oligodendrogliomas: Clinical, Morphologic and molecular analysis
  • Immunohistochemistry comparison of p40 and p63 expression in Non Small Cell Lunch Carcinomas
  • Expression of PLA2R in renal biopsy in diagnosis of Idiopathic membranous Nephropathy
  • Clinicopathological and cytogenetic study of patients diagnosed as aplastic / hypoplastic anemia.
  • Clinicopathological study of non granulomatous necrotizing lymphodenopathies.
  • A correlation of morphology, Cytochemistry and immunophenotyping in acute leukaemias
  • Clinicopathologic study of Adult renal tumors
  • Analysis of renal allograft biopsies froma tertiary care centre 
  • Clinicopathological study of thymoma                                                                                       
  • Clinical, morphologic and immunohistochemical profile of glioblastomas according to the updated WHO 2016 classification of CNS tumours
  • Clinicopathological significance of Endobronchial biopsies.
  • Histopathological analysis and grading of phyllodes tumor
  • Clinicopathological study of Nodal Diffuse Large B-cell lymphoma (DLBCL) with sub-grouping into germinal centre B-cell like (GCB) and non-germinal centre B-cell like (non GCB) using Imunohistochemistry.
  • Utility of DOG 1 immunohistochemistry in differentiating condroblastoma from other giant cell lesions
  • Study of clinical, morpholical, Immunohistochemical characterstics of ovarian tumours
  • Study of Histopathology of spleen - with emphasis on space occupying lesion.
  • A Prospective study to evaluate the utility of intra operative frogen section diagnosis
  • Clinical, Morphological and molecular features of diff use astrocytomas (WHO grade II & III).
  • Differential diagnosis of bone marroe fibrosis- a study from tertiary care center.
  • Immunohistochemical study of Anti Histone H 3.3 G34W antibody in graint cell tumor of bone and its mimics



Publications (2019-2021)

  1. S DemeN GollakotaPK Vanka,  TR Paul. A rare cause of cold agglutinin hemolytic anemia- Histiocytic sarcoma J Postgrad Med. 2019 ; 65: 190–191.
  2. Dixith R, Sara A, Vangala N, Uppin SG, Uppin MS, R Narendra A M, Paul TR. Clinicopathological spectrum of BCR-ABL-Negative myeloproliferative neoplasms with correlation with janus-associated kinase 2 mutation. Indian J Med Paediatr Oncol 2019;40:35-40.
  3. Padmasree S, Hui M, Uppin SG, Uppin MS, Sadashivudu G, Paul TR. Acute Myeloid Leukemia with Marrow Mastocytosis: Does It Affect Prognosis?.Clin Oncol 2019; 4: 1581.
  4. Hui MMeena AKRajasekhar LSireesha YAfshan JMridula RBorgohain RUppin MS Vasculitic Neuropathy: A Retrospective Analysis of Nerve Biopsies and Clinical Features from a Single Tertiary Care Center.Ann Indian Acad Neurol. 2019;22:180-186
  5. Challa SHui MJakati SUppin MSRajasekhar LKannan MALingappa LJagarlapudi MMK Juvenile idiopathic inflammatory myopathies: A clinicopathological study with emphasis on muscle histology.Indian J Pathol Microbiol. 2019;62:61-66.
  6. Sireesha YUppin MSGanti SAlugolu RMudumba VSBhattacharjee SNeeharika MLBastia JKanikannan MA. A Series of Biopsy-proven Patients with Immunoglobulin G4-related Neurological Disease. Ann Indian Acad Neurol. 2019;22:73-78.
  7. Sireesha YKanikannan MAPyal ASandeep GUppin MSKandadai RMJabeen SAVaraprasad RRajasekhar LNeeharika MLBorgohain R Patterns of peripheral neuropathy in Sjogren's syndrome in a tertiary care hospital from South India.Neurol India. 2019;67:S94-S99.
  8. Tallapaka KRanganath PRamachandran AUppin MSPerala SAggarwal SLakshmi DMeena AKDalal AB. Molecular and Histopathological Characterization of Patients Presenting with the Duchenne Muscular Dystrophy Phenotype in a Tertiary Care Center in Southern India.Indian Pediatr. 2019;56:556-559.
  9. Sangati LAlugolu RBhattacharjee SVijaya Saradhi MSahu BPUppin MSSadashivudu GIrukulla MM. A clinicopathologic study of surgically resected metastatic lesions of brain: A single institutional experience.Neurol India. 2019;
  10. Ansari FA, Manuel S, Dwivedi R, Boraiah SK, Raju SB, Uppin M, Sharma A. A Rare Case of Acute Kidney Injury Due to Levofloxacin-induced Crystal Nephropathy.Indian J Nephrol. 2019;29:424-426. 67:749-754.
  11. Gupta MKPolisetty RVSharma RGanesh RAGowda H, Purohit AKAnkathi PPrasad KMariswamappa KLakshmikantha AUppin MSSundaram CGautam PSirdeshmukh R. Altered transcriptional regulatory proteins in glioblastoma and YBX1 as a potential regulator of tumor invasion.Sci Rep. 2019;9:10986.
  12. Paramasivam AVenkatapathi CSandeep GMeena AKUppin MSMohapatra SPitceathly RDSThangaraj K. Homozygous R627W mutations in POLG cause mitochondrial DNA depletion leading to encephalopathy, seizures and stroke-like episodes.Mitochondrion. 2019;48:78-83.
  13. Bangaru VUppin MYadla MGudithi STaduri GRaju S. Isolated Vascular Lesions (IVL) in Early Allograft Biopsies: A Case Series. Indian J Nephrol. 2019;29:364-367
  14. S.Srikanth, PramodKumarPamu A  study of histopathological correlation  in patients of Psoriasis.IJSRO volume -8, issue -8/August 2019; 40:35-40.
  15. Pamu PK, Vangala N, Sabbavarapu P, Tandon A Utility of cytology in the diagnosis of parasitic infestation: A retrospective study. Trop Parasitol. 2019; 9(2):93-97.
  16. Pamu PK, Paul TR, Uppin MS, Uppin SS, Sadashivudu. Clinicopathological, immunophenotypic, cytogenetic and molecular pathology study of Burkitt lymphoma in a tertiary care institute. Indian J Pathol Oncol 2020; 7(1):131-136.
  17. Pramod Kumar Pamu, Radhika Kottu. Adrenal and extra adrenal paragangiloma: Aclinic pathological study from tertiary care hospital Sch J App Med Sci, Sep, 2019; 7(9): 3041-3044.
  18. T Sravani , Pamu Pramod Kumar , Aswani Tandon , Megha S Uppin , Shantiveer G Uppin , Amvr Narendra , Gundeti Sadashivudu , T Roshni Paul. Acute Promyelocytic Leukaemia: A Large Case Series from Southern India Based on Clinical, Pathological, Immunophenotypic, Cytogenetic and Molecular Studies National Journal of Laboratory Medicine. 2019 Oct, Vol-8(4): PO08-PO12
  19. Venu Ghodasara, Navatha Vangala, Tara Roshni Paul.Cytological diagnosis of Metastatic Ovarian Carcinoma in a young female presenting as Sister Mary Joseph's nodule. Cytological diagnosis of Metastatic Ovarian Carcinoma in a young female presenting as Sister Mary Joseph's nodule Medical Journal of D Y Patil Vidyapeeth.2019;12(6):540-543.
  20. Pamu P K, Paul T R, Uppin M S, Uppin S G, Sadashivudu, Clinico-pathological, immuno phenotypic, cytogenetic and molecular pathology study of Burkitt lymphoma in a tertiary care institute.Indian J Pathol Oncol 2020;7(1):131-136.
  21. Jyothi NN, Pamu PK, Paul TR, Uppin SG, Uppin MS, Gundeti S, Radhika K. Clinicopathological Study of Extensive Myelonecrosis.Annals of Pathology and Laboratory Medicine 2020; 7(3):A95-100.
  22. Kesarapu S, Vangala N, Uppin SG, Uppin MS, Paul TR, Rajasekhar L. Acute leukemia presenting with musculoskeletal manifestations: A case series. Indian J Med Paediatr Oncol 2020;41:29-33
  23. Hui M, Manchikatla R, Ramakrishna N, Uppin SG, Chandrasekhar P. Chronic osteomyelitis associated primary diffuse large B-cell lymphoma of femur. Report of a diagnostically challenging case.Journal of Case Reports: Clinical & Medical. 2020; 3(3):154.
  24. Madireddy N, Patil R, Uppin SG and Uppin MS. A rare case of gastric zygomycosis mimicking malignancy: Case report with review of literature.J Bacteriol Mycol 2020; 7(2): 1126.
  25. Thamtam VK, Uppin SG, Hui M, Kumar N N, Bhaskar K, Bala SC, Sadashivudu G, Paramjyothi G K. Validation of superiority of p40 over p63 in differentiating squamous cell carcinoma and adenocarcinoma lung.Indian J Med Paediatr Oncol 2020;41:535-42.
  26. Hui M, Uppin SG,  Paul TR, Jena S, Patil RS, Ranganath R. Need for re-classifying the rare Condition of ectopic hamartomatous thymoma based on tumor analysis.Archives of Otorhinolaryngology-Head & Neck Surgery. 2020;4(3):1
  27. Rani H S, Hui M, Uppin MS, Uppin SG, Sadashivudu G, Paul TR. Utility of immunohistochemistry on bone marrow trephine biopsy for the diagnosis and classification of acute leukemia.Indian J Med Paediatr Oncol 2020;41:683-7.
  28. Vangala N, Uppin SG, Uppin MS, Paul TR, Sadashivudu G. Ovarian serous carcinoma: A retrospective study of clinicopathological findings and postchemotherapy changes.Indian J Med Paediatr Oncol 2020;41:663-9
  29. Vavilapalli S, Madireddy N, Uppin MS, Kalidindi K, Gudithi S, Taduri G, Raju SB. Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases. Indian J Pathol Microbiol. 2020 ;63:226-229.
  30. Hassan R, Hui M, Sireesha Y, Afshan J, Meena AK, Uppin MS. Understanding Demyelination in Leprosy Neuropathy: A Nerve Biopsy Analysis.Ann Indian Acad Neurol. 2020;23:829-832. 
  31. Hui M, Uppin SG, Uppin MS, Madhav TV, Varma GS, Paul TR, Bheerappa N. Hepatocellular carcinoma: A clinicopathological and immunohistochemical study of 116 cases from a tertiary care hospital in Southern India.Indian J Cancer 2020; Ahead of print. Accepted on April 2020.
  32. Hui M, Balu B, Uppin SG, Uppin MS, Chandrasekhar P, Rao KN, Bhattacharjee S, Saradhi MV, Krishna YV Bone metastases: A compilation of 365 histologically verified cases spanning over two decades from a single center.IJPM Accepted on December 2020
  33. Pramod Kumar Pamu, Lupus anticoagulant LA screening &confirmation tests by dilute Russell viper venom time (DRVVT) method. International Journal of Clinical and Diagnostic Pathology2020;3(4):1215
  34. Parigi M, Hui M, Uppin SG, Kapoor A, Kumar N N, Bhaskar K, Stalin BJ, Sadashivudu G, Paramjyothi G K. Percutaneous core needle biopsy in the diagnosis of lung lesions: An experience on 280 consecutive cases from a university hospital in southern India.Lung India 2021;38:41-52.
  35. Jyothi N, Hui M, Uppin SG, Kumar N N, Bhaskar K, Paramjyothi G K Endobronchial biopsies in the diagnosis of lung lesions – A study of 204 consecutive cases from a single center in Southern India.Indian J Respir Care 2021;10:57-65.
  36. Pasala UJ, Hui M, Uppin SG, Kumar N N, Bhaskar K, Paramjyothi G K. Clinicopathological and immunohistochemical study of pulmonary neuroendocrine tumors – A single-institute experience. Lung India 2021;38:134-8.
  37. Rani, H.S., Hui, M., Manasa, P.L. Uppin SG, Uppin MS, Paul TR, Sadashivudu G. Bone Marrow Metastasis of Solid Tumors: A Study of 174 Cases Over 2 Decades from a Single Institution in India.Indian J Hematol Blood Transfus 2021.
  38. Sivakoti S, Uppin SG, Uppin MS, Tara RP, Prayaga Ak, Challa S. Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.Indian J Pathol Microbiol 2021;64:310-5
  39. Vangala N, Uppin S, G, Pamu P, K, Hui M, Nageshwara Rao K, Chandrashekar P: Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital.Acta Cytologica 2021;65:75-87.


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